Selected References for Oral-Systemic Articles

General

Costerton J, Keller D. Oral periopathogens and systemic effects. Gen Dent. 2007 May-June;55(3):210-15.

Geerts SO et al. Systemic release of endotoxins induced by gentle mastication: association with periodontitis severity. J Periodontol. 2002 Jan;73(1):73-78.

Gendron R, Grenier D, Maheu-Robert L-F. The oral cavity as a reservoir of bacterial pathogens for focal infections. Microbes and Infect. 2000; 2(8):897-906.

Keller, D and J Costerton. Oral Biofilm: Entry and Immune System Response. Compendium. 2009 Jan;30(1): 24-32.

Incidence of Periodontal Disease

Burt B. Research, Science, and Therapy Committee of the American Academy of Periodontology. Position paper: epidemiology of periodontal diseases. J Periodontol. 2005 Aug;76(8);1406-19.

Ciancio S. Improving oral health: current considerations. J Clin Periodontol. 2003;30 Suppl 5:4-6.

Peterson, PE. The World Oral Health Report, 2003: Continuous improvement of oral health in the 21^st century – the approach of the WHO Global Oral Health Programme. World Health Organization: Geneva, Switzerland, 2003.

US Department of Health and Human Services. Oral Health in America: A Report of the Surgeon General – Executive Summary. Rockville, MD: US Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health, 2000. J Calif Dent Assoc. 2000Sep;28(9):685-95.

Cardiovascular Disease

Angeli F et al. Association between periodontal disease and left ventricle mass in essential hypertension. Hypertension. 2003 Mar;41(3):488-92.

Cavrini F et al. Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. J Med Microbiol. 2005;54:93-96.

D’Aiuto F et al. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. Am Heart J. 2006 May;151(5):977-84.

Deshpande RG et al. Invasion of Aortic and Heart Endothelial Cells by Porphyromonas gingivalis.

Infect Immun. 1998 Nov; 66(11): 5337–43.

Desvarieux M et al. Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study. Circulation. 2005 Feb 8;111(5):576-82.

Ford PJ et al. Cardiovascular and oral disease interactions: what is the evidence? Prim Dent Care. 2007 Apr;14(2):59-66.

Furuichi Y et al. Associations of periodontal status with general health conditions and serum antibody titers for Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. J Periodontol. 2003 Oct;74(10):1491-97.

Gibson FC 3^rd et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E--deficient mice. Circulation. 2004 June 8;109(22):2801-6.

Golebiewska M et al. Periodontal condition in patients with cardiovascular diseases. Adv Med Sci. 2006;51 Suppl 1:69-72.

Inoue K et al. Association of periodontitis with increased white blood cell count and blood pressure. Blood Press. 2005;14(6):53-8,383; author reply 384.

Jain A et al. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003 Oct;71(10):6012-8.

Kozarov EV, et al. Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):E17-8.

Kuramitsu HK et al. Interactions of Porphyromonas gingivalis with host cells: implications for cardiovascular diseases. J Periodontol. 2003 Jan;74(1):85-9.

Kuramitsu HK et al. Role of periodontal bacteria in cardiovascular disease. Ann Periodontol. 2001 Dec;6(1)41-7.

Li L, Messas E, Batista EL et al. Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-dificient murine model. Circulation. 2002 Feb 19;105(7):861-7.

Maiborodin IV et al. Changes in gum in cases of arterial hypertension combination with periodontitis. Stomatologiia (Mosk). 2005:84(6):15-19.

Martin MC, Andres MT, Ffierro JF, Mendez FJ. Endarteritis and Mycotic Aortic Aneurysm caused by an Oral Strain of Actinobacillus actinomycetemcomitans. Euro J Clin Microb Infect Dis. 1998 Feb;17(2):104-7.

Nakano K, Inaba H, Nomura H et al. Distribution of Porphyromonas gingivalis fimA genetypes in cardiovascular specimens from Japanese patients. Oral Micriol Immunol. 2008 Apr;23(2):170-2.

Papaganagiotou D et al. Periodontitis is associated with Platelet Activation. Atherosclerosis. 2008:May28.( Epub ahead of print.)

Pussinen PJ, Alfthan G, Rissanen H et al. Antibodies to periodontal pathogens and stroke risk. Stroke. 2004 Sep;35(9):2020-3.

Pussinen PJ, Toumisto K, Jousilhasti P et al. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc T. 2007 Jun;27(6);1433-9.

Pussinen PJ, Vilkuna-Rautiainen T, Alfthan G et al. Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide. Atherosc, Thrombs and Vascular Biol. 2004 Nov;24(11):2174-80.

Zaremba M. et al. Periodontitis as a risk factor of coronary artery disease? Adv Med Sci. 2006;51 Suppl 1:34-9.

Diabetes

Arnush M et al. IL-1 produced and released endogenously within human islets inhibits beta cell function. J Clin Invest. 1998 Aug 1;102(3):516-26.

Engebretson S et al. Plasma levels of tumour necrosis factor-a in patients with chronic periodontitis and type 2 diabetes. J Clin Periodontol. 2007 Jan;34(1):18-24. Epub 2006 Nov 20.

Grossi, SG. Treatment of periodontal disease and control of diabetes: an assessment of the evidence and need for future research. Ann Periodontol. 2001 Dec;6(1):138-45.

Hotamisligil GS et al. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995 May;95(5):2409-15.

Iacopino AM et al. Periodontitis and diabetes interrelationships: role of inflammation. Ann Periodontol 2001 Dec;6(1);125-37.

Iwamoto Y, et al. The effects of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol. 2001 Jun;72(6);774-8.

Kesavalu L et al. In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2002 Jun;17(3):177-80.

Noack B, Genco RJ, Trevisan M et al. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol. 2001;72(9):1221-7.

Pischon N. et al. Obesity, Inflammation and Periodontal Disease J Dent Res. 2007 May;86(5);400-9.

Schara R et al. Periodontal disease and diabetes metabolic control: a full-mouth disinfection approach. J Int Acad Periodontol. 2006 Apr;8(2):61-6.

Seinost G, Wimmer G, Skerget M et al. Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis. Am Heart J. 2005 Jun;149(6):1050-4.

Slade GD, Offenbacher S, Geck JD et al. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res. 2000 Jan;79(1):49-57.

Steer SA et al. Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med. 2006 Feb;3(2):e17.

Tonetti MS, D’Aiuto F, Nibali , et al. Treatment of periodontitis and endothelial function. New Eng J Med. 2007 Mar1;356(9):911-20.

Pregnancy

Barak, S et al. Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol. 2007 Apr;78(4):670-6.

Boggess KA et al. Antepartum vaginal bleeding, fetal exposure to oral pathogens and risk for preterm birth at <35 weeks of gestation. Am J Obstet Gynecol. 2006 Apr;194(4):954-60.

Cota LO et al. Association between maternal periodontitis and an increased risk of preeclampsia. J Periodontol. 2006 Dec;77(12):2063-9.

Dasanayake AP, Le Y, Wiener H. et al. Salivary Actinomyces naeslundii genospecies 2 and Lactobacillus casei levels predict pregnancy outcomes. J Periodontol. 2005 Feb;76(2):171-7.

Gazolla CM et al. Evaluation of the incidence of preterm low birth weight in patients undergoing periodontal therapy. J Periodontol. 2007 May;78(5):842-8.

Kunnen A et al. Women with a recent history of early-onset pre-eclampsia have a worse periodontal condition. J Clin Periodontol. 2007 Mar;34(3)202-7.

Lin D et al. Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1/Th2 cytokine ratio, and fetal growth restriction. Infect Immun. 2003 Sep;71(9):5163–8.

McGaw T. Periodontal disease and preterm delivery of low-birth-weight infants. J Can Dent Assn. 2002 Mar;68(3):165-9.

Offenbacher S et al. Effects of Campylobacter rectus infection on murine placenta, fetal and neonatal survival, and brain development. J Periodontol. 2005 Nov;76(11 Suppl):2133-43.

Romero G, Gotsch F, Pineles B, Kusanovic JP. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications and fetal injury. Nutr Rev. 2007 Dec;65(12 Pt 2):S194-202.

Walter C et al. Porphyromonas gingivalis Strain-Dependent Activation of Human Endothelial Cells. Infection and Immun. 2004 Oct;72(10):5910-8.

Alzheimer’s Disease

MacDonald AB. Alzheimer’s neuroborreliosis with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes. Med Hypotheses. 2007;68(4):822-5.

Miklossy J et al. Beta-amyloid deposition and Alzheimer’s type changes induced by Borrelia spirochetes. Neurobiol Aging. 2006 Feb;27(2):228-36.

Riviere GR et al. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer’s disease. Oral Microbiol Immunol. 2002 Apr;17(2):113-8.

Arthritic Alteration and Oral Pathogens

Hamada Y, Kondoh T, Holmlund AB et al. Cytokine and clinical predictors for treatment outcome of visually guided temporomandibular joint irrigation in patients with chronic closed lock. J Oral Maxillofac Surg. 2008 Jan;66(1):29-34.

Henry CH, Hughes CV, Gerard HC et al. Reactive arthritis: preliminary microbiological analysis of the human temporomandibular joint. J Oral Maxillofac Surg. 2000 Oct;58(10):1137-42. Discussion 1143-4.

Shinoda C, Takaku S. Interleukin-1 beta, interleukin-6 and tissue inhibitor of metalloproteinase-1 in the synovial fluid of the temporomandibular joint with respect to cartilage destruction. Oral Dis. 2000 Nov;6(6):383-90.

Respiratory Disease

Koyama S, Sato E, Nomura H et al. The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cells and fibroblasts. Eur Respir J. 1999 Sep;14(3):545-52.

Scannapieco FA et al. Oral bacteria and respiratory infection: effects on respiratiory pathogen adhesion and epithelial cell proinflammatory cytokine production. Ann Periodontol. 2001 Dec;6(1):78-86.

Sona CS et al. The impact of a Simple, Low-cost Oral Care Protocol on Ventilator-associated Pneumonia Rates in a Surgical Intensive Care Unit. J Intensive Care Med. 2008 Nov 17 (Epub ahead of print).