Selected Reference for Oral Systemic Articles

Costerton J, Keller D. Oral periopathogens and systemic effects. Gen Dent. 2007 May-June;55(3):210-15.

Geerts SO et al. Systemic release of endotoxins induced by gentle mastication: association with periodontitis severity. J Periodontol. 2002 Jan;73(1):73-78.

 

Cardiovascular Disease

Angeli F et al. Association between periodontal disease and left ventricle mass in essential hypertension. Hypertension. 2003 Mar;41(3):488-92.

D’Aiuto F et al. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. Am Heart J. 2006 May;151(5):977-84.

Deshpande RG et al. Invasion of Aortic and Heart Endothelial Cells by Porphyromonas gingivalis. Infect Immun. 1998 Nov.; 66(11): 5337–43.

Desvarieux M et al. Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study. Circulation. 2005 Feb 8;111(5):576-82.

Ford PJ et al. Cardiovascular and oral disease interactions: what is the evidence? Prim Dent Care. 2007 Apr;14(2):59-66.

Furuichi Y et al. Associations of periodontal status with general health conditions and serum antibody titers for Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans.  J Periodontol. 2003 Oct;74(10):1491-97.

Gibson FC 3rd et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E--deficient mice. Circulation. 2004 June 8;109(22):2801-6.

Golebiewska M et al. Periodontal condition in patients with cardiovascular diseases. Adv Med Sci. 2006;51 Suppl 1:69-72.

Inoue K et al. Association of periodontitis with increased white blood cell count and blood pressure. I. 2005;14(6):383; author reply 384.

Jain A et al. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003 Oct;71(10):6012-8.

Kozarov EV, et al. Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):E17-8.

Kuramitsu HK et al. Interactions of Porphyromonas gingivalis with host cells: implications for cardiovascular diseases. J Periodontol. 2003 Jan;74(1):85-9.

Kuramitsu HK et al. Role of periodontal bacteria in cardiovascular disease. Ann Periodontol. 2001 Dec;6(1)41-7.

Maiborodin IV et al. Changes in gum in cases of arterial hypertension combination with periodontitis. Stomatologiia (Mosk). 2005:84(6):15-19.

 

Diabetes

Arnush M et al. IL-1 produced and released endogenously within human islets inhibits beta cell function.  J Clin Invest. 1998 Aug 1;102(3):516-26.

Engebretson S et al. Plasma levels of tumour necrosis factor-a in patients with chronic periodontitis and type 2 diabetes. J Clin Periodontol. 2007 Jan;34(1):18-24. Epub 2006 Nov 20.

Grossi, SG. Treatment of periodontal disease and control of diabetes: an assessment of the evidence and need for future research. Ann Periodontol. 2001 Dec;6(1):138-45.

Hotamisligil GS et al. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995 May;95(5):2409-15.

Iacopino AM et al. Periodontitis and diabetes interrelationships: role of inflammation..Ann Periodontol 2001 Dec;6(1);125-37.

Iwamoto Y, et al. The effects of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol. 2001 Jun;72(6);774-8.

Kesavalu L et al. In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2002 Jun;17(3):177-80.

Pischon N. et al. Obesity, Inflammation and Periodontal Disease J Dent Res. 2007 May;86(5);400-9.

Schara R et al. Periodontal disease and diabetes metabolic control: a full-mouth disinfection approach. J Int Acad Periodontol. 2006 Apr;8(2):61-6.

Steer SA et al. Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med. 2006 Feb;3(2):e17.

  

Pregnancy

Barak, S et al. Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol. 2007 Apr;78(4):670-6.

 Lin D et al. Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1/Th2 cytokine ratio, and fetal growth restriction. Infect Immun. 2003 Sep;71(9):5163–8.

 Cota LO et al. Association between maternal periodontitis and an increased risk of preeclampsia. J Periodontol. 2006 Dec;77(12):2063-9.

 Gazolla CM et al. Evaluation of the incidence of preterm low birth weight in patients undergoing periodontal therapy. J Periodontol. 2007 May;78(5):842-8.

 

Alzheimer’s Disease

MacDonald AB. Alzheimer’s neuroborreliosis with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes. Med Hypothesis. 2007;68(4):822-5.

Miklossy J et al. Beta-amyloid deposition and Alzheimer’s type changes induced by Borrelia spirochetes. Neurobiol Aging. 2006 Feb;27(2):228-36.

Riviere GR et al. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer’s disease. Oral Microbiol Immunol. 2002 Apr;17(2):113-8.